Exogenous Klotho ameliorates extracellular matrix degradation and angiogenesis in intervertebral disc degeneration via inhibition of the Rac1/ PAK1/MMP-2 signaling axis

Yi, YY; Chen, H; Zhang, SB; Xu, HW; Fang, XY; Wang, SJ

Wang, SJ (通讯作者),150 Jimo RD, Shanghai 200120, Peoples R China.

MECHANISMS OF AGEING AND DEVELOPMENT, 2022; 207 ():

Abstract

Intervertebral disc degeneration (IDD) is highly ubiquitous in the aged population and is an essential factor for low back pain and spinal disability.......

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