Irreversibility of arsenic trioxide induced PML/RAR alpha fusion protein solubility changes

Maimaitiyiming, Y; Shao, YM; Chen, WZ; Jiang, Y; Bu, N; Ya, L; Wang, QQ; Lu, XY; Naranmandura, H

Naranmandura, H (reprint author), Zhejiang Univ, Dept Hematol, Affiliated Hosp 1, Sch Med, Hangzhou 310058, Zhejiang, Peoples R China.; Naranmandura, H (reprint author), Zhejiang Univ, Sch Med, Dept Pharmacol, Hangzhou 310058, Zhejiang, Peoples R China.;

METALLOMICS, 2019; 11 (12): 2089

Abstract

Arsenic trioxide (As2O3) is one of the most effective drugs for the treatment of acute promyelocytic leukemia (APL), and induces the degradation of ch......

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