Muscle proteolysis via ubiquitin-proteasome system (UPS) is activated by BthTx-I Lys49 PLA(2) but not by BthTx-II Asp49 PLA(2) and Bothrops jararacussu venom

Kenzo-Kagawa, B; Vieira, WF; Cogo, JC; da Cruz-Hofling, MA

da Cruz-Hofling, MA (corresponding author), State Univ Campinas UNICAMP, Inst Biol, Dept Biochem & Tissue Biol, Rua Monteiro Lobato 255, BR-13083970 Campinas, SP, Brazil.

TOXICOLOGY AND APPLIED PHARMACOLOGY, 2020; 402 ():

Abstract

Bites by viperid snakes belonging to Bothrops genus produce fast and intense local edema, inflammation, bleeding and myonecrosis. In this study, we in......

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