IL-1 induces mitochondrial translocation of IRAK2 to suppress oxidative metabolism in adipocytes

Zhou, H; Wang, H; Yu, MJ; Schugar, RC; Qian, W; Tang, FQ; Liu, WW; Yang, H; McDowell, RE; Zhao, JJ; Gao, J; Dongre, A; Carman, JA; Yin, M; Drazba, JA; Dent, R; Hine, C; Chen, YR; Smith, JD; Fox, PL; Brown, JM; Li, XX

Li, XX (corresponding author), Cleveland Clin, Lerner Res Inst, Dept Inflammat & Immun, Cleveland, OH 44106 USA.

NATURE IMMUNOLOGY, 2020; 21 (10): 1219

Abstract

Chronic inflammation is a common feature of obesity, with elevated cytokines such as interleukin-1 (IL-1) in the circulation and tissues. Here, we rep......

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