Cell-based cccDNA reporter assay combined with functional genomics identifies YBX1 as HBV cccDNA host factor and antiviral candidate target

Verrier, ER; Ligat, G; Heydmann, L; Doernbrack, K; Miller, J; Maglott-Roth, A; Jühling, F; El Saghire, H; Heuschkel, MJ; Fujiwara, N; Hsieh, SY; Hoshida, Y; Root, DE; Felli, E; Pessaux, P; Mukherji, A; Mailly, L; Schuster, C; Brino, L; Nassal, M; Baumert, TF

Verrier, ER; Baumert, TF (通讯作者)，Univ Strasbourg, Inst Rech les Malad Virales & Hepat, INSERM, UMRS 1110, Strasbourg, France.;Nassal, M (通讯作者)，Univ Hosp Freiburg, Dept Internal Med Mol Biol 2, Freiburg, Germany.;Baumert, TF (通讯作者)，Nouvel Hop Civil, Inst Hosp Univ, Pole Hepato digestif, Strasbourg, France.

GUT, 2023; 72 (9): 1745

Abstract

Objectives Chronic hepatitis B virus (HBV) infection is a leading cause of liver disease and hepatocellular carcinoma. A key feature of HBV replicatio......

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