Two Antagonistic MALT1 Auto-Cleavage Mechanisms Reveal a Role for TRAF6 to Unleash MALT1 Activation

Ginster, S; Bardet, M; Unterreiner, A; Malinverni, C; Renner, F; Lam, S; Freuler, F; Gerrits, B; Voshol, J; Calzascia, T; Regnier, CH; Renatus, M; Nikolay, R; Israel, L; Bornancin, F

Bornancin, F (reprint author), Novartis Inst BioMed Res, Novartis Campus, Basel, Switzerland.

PLOS ONE, 2017; 12 (1):

Abstract

The paracaspase MALT1 has arginine-directed proteolytic activity triggered by engagement of immune receptors. Recruitment of MALT1 into activation com......

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