Translational Activation of ATF4 through Mitochondrial Anaplerotic Metabolic Pathways Is Required for DLBCL Growth and Survival

Li, M; Teater, MR; Hong, JY; Park, NR; Duy, C; Shen, H; Wang, L; Chen, ZM; Cerchietti, L; Davidson, SM; Lin, HN; Melnick, AM

Lin, HN (通讯作者)，Cornell Univ, Howard Hughes Med Inst, Dept Chem & Chem Biol, Ithaca, NY 14853 USA.;Melnick, AM (通讯作者)，Weill Cornell Med, Dept Med, 413 E 69th St,BB-1430, New York, NY 10021 USA.;Melnick, AM (通讯作者)，Weill Cornell Med, Dept Pharmacol, 413 E 69th St,BB-1430, New York, NY 10021 USA.

BLOOD CANCER DISCOVERY, 2022; 3 (1):

Abstract

Diffuse large B-cell lymphomas (DLBCL) are broadly dependent on anaplerotic metabolism regulated by mitochondrial SIRT3. Herein we fi nd that translat......

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