Acquired temozolomide resistance in MGMT-deficient glioblastoma cells is associated with regulation of DNA repair by DHC2

Yi, GZ; Huang, GL; Guo, ML; Zhang, XA; Wang, H; Deng, SZ; Li, YM; Xiang, W; Chen, ZY; Pan, J; Li, ZY; Yu, L; Lei, BX; Liu, YW; Qi, ST

Liu, YW (reprint author), Nanfang Hosp, Lab Precis Neurosurg, New Lab Bldg,Guangzhou Dadao Bei St, Guangzhou, Guangdong, Peoples R China.; Qi, ST (reprint author), Nanfang Hosp, Dept Neurosurg, Guangzhou Dadao Bei St, Guangzhou, Guangdong, Peoples R China

BRAIN, 2019; 142 (): 2352

Abstract

The acquisition of temozolomide resistance is a major clinical challenge for glioblastoma treatment. Chemoresistance in glioblastoma is largely attrib......

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