Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation

Xian, HX; Liu, Y; Nilsson, AR; Gatchalian, R; Crother, TR; Tourtellotte, WG; Zhang, Y; Aleman-Muench, GR; Lewis, G; Chen, WX; Kang, S; Luevanos, M; Trudler, D; Lipton, SA; Soroosh, P; Teijaro, J; de la Torre, JC; Arditi, M; Karin, M; Sanchez-Lopez, E

Karin, M (corresponding author), UCSD, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, Sch Med, La Jolla, CA 92093 USA.

IMMUNITY, 2021; 54 (7): 1463

Abstract

Acute respiratory distress syndrome (ARDS), an inflammatory condition with high mortality rates, is common in severe COVID-19, whose risk is reduced b......

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