Mutant Kras co-opts a proto-oncogenic enhancer network in inflammation-induced metaplastic progenitor cells to initiate pancreatic cancer

Li, Y; He, Y; Peng, JY; Su, ZD; Li, ZY; Zhang, BJ; Ma, J; Zhuo, ML; Zou, D; Liu, XD; Liu, XH; Wang, WZ; Huang, D; Xu, MY; Wang, JB; Deng, HT; Xue, J; Xie, W; Lan, X; Chen, M; Zhao, YP; Wu, WM; David, CJ

David, CJ (corresponding author), Tsinghua Univ, Sch Med, Beijing, Peoples R China.; Zhao, YP; David, CJ (corresponding author), Peking Univ Tsinghua Ctr Life Sci, Beijing, Peoples R China.; Zhao, YP; Wu, WM (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Gen Surg, Beijing, Peoples R China.

NATURE CANCER, 2021; 2 (1): 49

Abstract

Kras-activating mutations display the highest incidence in pancreatic ductal adenocarcinoma. Pancreatic inflammation accelerates mutant Kras-driven tu......

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