Enantioselective Regulation of Short-Chain Dehydrogenases via Key Sites in its Loop and Adjacent Regions for the Enantiodivergent Reduction of Difficult-To-Reduce Ketones

Qin, L; Su, X; Wang, J; Wu, LJ; Zou, M; Gu, J; Xu, Y; Nie, Y

Nie, Y (通讯作者)，Jiangnan Univ, Sch Biotechnol, Lab Brewing Microbiol & Appl Enzymol, Wuxi 214122, Peoples R China.;Nie, Y (通讯作者)，Jiangnan Univ, Key Lab Ind Biotechnol, Minist Educ, Wuxi 214122, Peoples R China.;Nie, Y (通讯作者)，Jiangnan Univ, Int Joint Res Lab Brewing Microbiol & Appl Enzymol, Wuxi 214122, Peoples R China.;Nie, Y (通讯作者)，Jiangnan Univ, State Key Lab Food Sci & Technol, 1800 Lihu Rd, Wuxi 214122, Peoples R China.

ADVANCED SYNTHESIS & CATALYSIS, 2023; 365 (23): 4205

Abstract

Short-chain dehydrogenases (SDRs) are powerful catalysts for the asymmetric reduction of prochiral ketones in pharmaceutical products. Herein, through......

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