Molecular dynamics simulations corroborate recombinant expression studies carried out on three αIIb β-propeller mutations reported in Indian Glanzmann thrombasthenia patients

Chandrasekaran, FP; Vishal, A; Arora, U; Kumar, SU; George, CPD; Nelson, EJR

Nelson, EJR (通讯作者)，Vellore Inst Technol, Sch Biosci & Technol, Dept Integrat Biol, Gene Therapy Lab, Vellore 632014, India.

JOURNAL OF CELLULAR BIOCHEMISTRY, 2023; 124 (7): 989

Abstract

Mutations in the alpha IIb beta-propeller domain have long been known to disrupt heterodimerization and intracellular trafficking of alpha IIb beta 3 ......

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