Develop adult extrapolation to pediatrics and pediatric dose optimization based on the physiological pharmacokinetic model of azithromycin

Liang, LH; Li, WT; Zhang, ZH; Li, DY; Pu, SJ; Xiang, RW; Zhai, F

Xiang, RW (通讯作者)，Shenyang Pharmaceut Univ, Dept Biomed Informat, Shenyang 110016, Liaoning, Peoples R China.;Zhai, F (通讯作者)，Shenyang Pharmaceut Univ, Comp Teaching & Res Sect, Shenyang 110016, Liaoning, Peoples R China.

BIOPHARMACEUTICS & DRUG DISPOSITION, 2023; 44 (3): 245

Abstract

Physiologically-based pharmacokinetic (PBPK) models are more frequently used for supporting pediatric dose selection in small-molecule drugs. Through ......

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