Germline IKAROS dimerization haploinsufficiency causes hematologic cytopenias and malignancies

Kuehn, HS; Niemela, JE; Stoddard, J; Mannurita, SC; Shahin, T; Goel, S; Hintermeyer, M; Heredia, RJ; Garofalo, M; Lucas, L; Singh, S; Tondo, A; Jacobs, Z; Gahl, WA; Latour, S; Verbsky, J; Routes, J; Cunningham-Rundles, C; Boztug, K; Gambineri, E; Fleisher, TA; Chandrakasan, S; Rosenzweig, SD

Kuehn, HS; Rosenzweig, SD (corresponding author), NIH, Immunol Serv, Dept Lab Med, Ctr Clin, Bldg 10,Room 2C306,10 Ctr Dr,MSC1508, Bethesda, MD 20892 USA.

BLOOD, 2021; 137 (3): 349

Abstract

IKAROS is a transcription factor forming homo- and heterodimers and regulating lymphocyte development and function. Germline mutations affecting the I......

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