Golgi apparatus-synthesized sulfated glycosaminoglycans mediate polymerization and activation of the cGAMP sensor STING

Fang, R; Jiang, QF; Guan, YK; Gao, PF; Zhang, R; Zhao, Z; Jiang, ZF

Jiang, ZF (corresponding author), Peking Univ, Sch Life Sci, Key Lab Cell Proliferat & Differentiat, Minist Educ, Beijing 100871, Peoples R China.; Jiang, ZF (corresponding author), Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China.

IMMUNITY, 2021; 54 (5): 962

Abstract

Activation of the cyclic guanosine monophosphate (GMP)-AMP (cGAMP) sensor STING requires its translocation from the endoplasmic reticulum to the Golgi......

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