Design and synthesis of selective degraders of EGFR(L858R/T790M) mutant

Zhang, X; Xu, F; Tong, LJ; Zhang, T; Xie, H; Lu, XY; Ren, XM; Ding, K

Ren, XM; Ding, K (corresponding author), Jinan Univ, Int Cooperat Lab Tradit Chinese Med Modernizat &, Guangzhou City Key Lab Precis Chem Drug Dev, Sch Pharm,Minist Educ MOE China, 601 Huangpu Ave West, Guangzhou 510632, Peoples R China.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020; 192 ():

Abstract

A series of PROTAC (proteolysis targeting chimera) based selective EGFR(L858R/T790M) (leucine 858 to arginine 858 mutation and threonine 790 to methio......

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