Understanding the influence of AMG 510 on the structure of KRASG(12C) empowered by molecular dynamics simulation

Li, Y; Han, L; Zhang, ZD

Zhang, ZD (通讯作者)，China Agr Univ, Coll Biol Sci, State Key Lab Agrobiotechnol, Beijing 100193, Peoples R China.;Han, L (通讯作者)，Tianjin Med Univ Canc, Natl Clin Res Ctr Canc,Inst & Hosp, Key Lab Canc Prevent & Therapy, Key Lab Canc Immunol & Biotherapy,Canc Mol Diagn, Tianjin, Peoples R China.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2022; 20 (): 1056

Abstract

The KRAS(G12C) mutant is often associated with human cancers, and AMG 510 as a promising covalent inhibitor of KRAS(G12C) has achieved surprising effi......

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