Discovery of N-substituted-endo-3-(8-aza-bicyclo[3.2.1]oct-3-yl)-phenol and -phenyl carboxamide series of mu-opioid receptor antagonists

Jiang, L; Beattie, DT; Jacobsen, JR; Kintz, S; Obedencio, GP; Saito, D; Stergiades, I; Vickery, RG; Long, DD

Long, DD (reprint author), Theravance Biopharma US Inc, 901 Gateway Blvd, San Francisco, CA 94080 USA.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017; 27 (13): 2926

Abstract

Gastrointestinal dysfunction as a consequence of the use of opioid analgesics is of significant clinical concern. First generation drugs to treat thes......

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