Cryo-EM structures of human GMPPA-GMPPB complex reveal how cells maintain GDP-mannose homeostasis

Zheng, LQ; Liu, Z; Wang, Y; Yang, F; Wang, JR; Huang, WJ; Qin, J; Tian, M; Cai, XT; Liu, XH; Mo, XM; Gao, N; Jia, D

Gao, N (corresponding author), Peking Univ, Acad Adv Interdisciplinary Studies, Sch Life Sci, Peking Tsinghua Joint Ctr Life Sci,State Key Lab, Beijing, Peoples R China.; Jia, D (corresponding author), Sichuan Univ, West China Univ Hosp 2, Key Lab Birth Defects & Related Dis Women & Child, State Key Lab Biotherapy,Dept Pediat, Chengdu, Peoples R China.

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2021; 28 (5): 443

Abstract

Structural elucidation and functional analysis of the human GMPPA-GMPPB complex reveals how GMPPA acts as a 'sensor' of GDP-mannose to allosterically ......

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