Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies

Chew, HY; De Lima, PO; Cruz, JLG; Banushi, B; Echejoh, G; Hu, LB; Joseph, SR; Lum, B; Rae, J; O'Donnell, JS; de Long, LM; Okano, S; King, B; Barry, R; Moi, D; Mazzieri, R; Thomas, R; Souza-Fonseca-Guimaraes, F; Foote, M; McCluskey, A; Robinson, PJ; Frazer, IH; Saunders, NA; Parton, RG; Dolcetti, R; Cuff, K; Martin, JH; Panizza, B; Walpole, E; Wells, JW; Simpson, F

Simpson, F (corresponding author), Univ Queensland, Diamantina Inst, Woolloongabba, Qld 4102, Australia.

CELL, 2020; 180 (5): 895

Abstract

A safe and controlled manipulation of endocytosis in vivo may have disruptive therapeutic potential. Here, we demonstrate that the anti-emetic/anti-ps......

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