Autophagy-dependent ferroptosis drives tumor-associated macrophage polarization via release and uptake of oncogenic KRAS protein

Dai, EY; Han, L; Liu, J; Xie, YC; Kroemer, G; Klionsky, DJ; Zeh, HJ; Kang, R; Wang, J; Tang, DL

Tang, DL (corresponding author), UT Southwestern Med Ctr, Dept Surg, Dallas, TX 75390 USA.; Wang, J (corresponding author), Jilin Univ, Dept Resp Med, China Japan Union Hosp, Changchun, Jilin, Peoples R China.

AUTOPHAGY, 2020; 16 (11): 2069

Abstract

KRAS is the most frequently mutated oncogene in human neoplasia. Despite a large investment to understand the effects of KRAS mutation in cancer cells......

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