A Burned-Out CD8(+) T-cell Subset Expands in the Tumor Microenvironment and Curbs Cancer Immunotherapy

Sanmamed, MF; Nie, XX; Desai, SS; Villaroel-Espindola, F; Badri, T; Zhao, DJ; Kim, AW; Ji, L; Zhang, TX; Quinlan, E; Cheng, XX; Han, X; Vesely, MD; Nassar, AF; Sun, JW; Zhang, Y; Kim, TK; Wang, J; Melero, I; Herbst, RS; Schalper, KA; Chen, LP

Schalper, KA (corresponding author), Yale Univ, Sch Med, 310 Cedar St, New Haven, CT 06520 USA.; Chen, LP (corresponding author), Yale Univ, Sch Med, 300 George St,Suite 203A, New Haven, CT 06510 USA.

CANCER DISCOVERY, 2021; 11 (7): 1700

Abstract

Specific mechanisms by which tumor-infiltrating lymphocytes (TIL) become dysfunctional remain poorly understood. Here, we employed a two-pronged appro......

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