Directed evolution and selection of biostable l-DNA aptamers with a mirror-image DNA polymerase

Chen, J; Chen, MY; Zhu, TF

Zhu, TF (通讯作者),Tsinghua Univ, Beijing Adv Innovat Ctr Struct Biol, Beijing Frontier Res Ctr Biol Struct, Sch Life Sci,Tsinghua Peking Ctr Life Sci, Beijing, Peoples R China.;Zhu, TF (通讯作者),Westlake Univ, Sch Life Sci, Hangzhou, Zhejiang, Peoples R China.;Zhu, TF (通讯作者),Westlake Lab Life Sci & Biomed, Hangzhou, Zhejiang, Peoples R China.

NATURE BIOTECHNOLOGY, 2022; 40 (11): 1601

Abstract

Mirror-image aptamers made from chirally inverted nucleic acids are nuclease-resistant and exceptionally biostable, opening up opportunities for uniqu......

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