Tumour-reprogrammed stromal BCAT1 fuels branched-chain ketoacid dependency in stromal-rich PDAC tumours

Zhu, ZW; Achreja, A; Meurs, N; Animasahun, O; Owen, S; Mittal, A; Parikh, P; Lo, TW; Franco-Barraza, J; Shi, JQ; Gunchick, V; Sherman, MH; Cukierman, E; Pickering, AM; Maitra, A; Sahai, V; Morgan, MA; Nagrath, S; Lawrence, TS; Nagrath, D

Nagrath, D (corresponding author), Univ Michigan, Lab Syst Biol Human Dis, Ann Arbor, MI 48109 USA.; Nagrath, D (corresponding author), Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA.; Nagrath, D (corresponding author), Univ Michigan, Biointerfaces Inst, Ann Arbor, MI 48109 USA.; Nagrath, D (corresponding author), Univ Michigan, Dept Chem Engn, Ann Arbor, MI 48109 USA.; Nagrath, D (corresponding author), Univ Michigan, Rogel Canc Ctr, Ann Arbor, MI 48109 USA.

NATURE METABOLISM, 2020; 2 (8): 775

Abstract

Branched-chain amino acids (BCAAs) supply both carbon and nitrogen in pancreatic cancers, and increased levels of BCAAs have been associated with incr......

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