Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer

Ruscetti, M; Morris, JP; Mezzadra, R; Russell, J; Leibold, J; Romesser, PB; Simon, J; Kulick, A; Ho, YJ; Fennell, M; Li, JY; Norgard, RJ; Wilkinson, JE; Alonso-Curbelo, D; Sridharan, R; Heller, DA; de Stanchina, E; Stanger, B; Sherr, CJ; Lowe, SW

Lowe, SW (corresponding author), Mem Sloan Kettering Canc Ctr, Dept Canc Biol & Genet, New York, NY 10065 USA.; Lowe, SW (corresponding author), Howard Hughes Med Inst, Chevy Chase, MD 20815 USA.

CELL, 2020; 181 (2): 424

Abstract

KRAS mutant pancreatic ductal adenocarcinoma (PDAC) is characterized by a desmoplastic response that promotes hypovascularity, immunosuppression, and ......

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