Metabolic Activation and Cytotoxicity of Labetalol Hydrochloride Mediated by Sulfotransferases

Yang, L; Xin, LH; Shi, JZ; Li, W; Tian, M; Hu, ZX; Peng, Y; Zheng, J

Peng, Y; Zheng, J (corresponding author), Shenyang Pharmaceut Univ, Wuya Coll Innovat, Shenyang 110016, Liaoning, Peoples R China.; Zheng, J (corresponding author), Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Key Lab Pharmaceut Guizhou Prov, Guiyang 550025, Guizhou, Peoples R China.; Zheng, J (corresponding author), Guizhou Med Univ, Key Lab Environm Pollut Monitoring & Dis Control, Minist Educ, Guiyang 550025, Guizhou, Peoples R China.

CHEMICAL RESEARCH IN TOXICOLOGY, 2021; 34 (6): 1612

Abstract

Labetalol hydrochloride (LHCl), an alpha- and beta-adrenoreceptor blocker, is widely used for the treatment of hypertension as well as angina pectoris......

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