Common variants in SOX-2 and congenital cataract genes contribute to age-related nuclear cataract

Yonova-Doing, E; Zhao, WT; Igo, RP; Wang, CL; Sundaresan, P; Lee, KE; Jun, GR; Alves, AC; Chai, XR; Chan, ASY; Lee, MC; Fong, A; Tan, AG; Khor, CC; Chew, EY; Hysi, PG; Fan, Q; Chua, J; Chung, J; Liao, JM; Colijn, JM; Burdon, KP; Fritsche, LG; Swift, MK; Hilmy, MH; Chee, ML; Tedja, M; Bonnemaijer, PWM; Gupta, P; Tan, QNS; Li, Z; Vithana, EN; Ravindran, RD; Chee, SP; Shi, Y; Liu, WT; Su, XY; Sim, XL; Shen, Y; Wang, YX; Li, HT; Tham, YC; Teo, YY; Aung, T; Small, KS; Mitchell, P; Jonas, JB; Wong, TY; Fletcher, AE; Klaver, CCW; Klein, BEK; Wang, JJ; Iyengar, SK; Hammond, CJ; Cheng, CY

Hammond, CJ (corresponding author), Kings Coll London, Sch Life Course Sci, Dept Twin Res & Genet Epidemiol, London SE1 7EH, England.; Cheng, CY (corresponding author), Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore 168751, Singapore.; Cheng, CY (corresponding author), Singapore Gen Hosp, Dept Pathol, Histol, Singapore 169856, Singapore.; Hammond, CJ (corresponding author), Kings Coll London, Dept Ophthalmol, London SE5 9RS, England.; Cheng, CY (corresponding author), Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Ophthalmol, Singapore 117597, Singapore.

COMMUNICATIONS BIOLOGY, 2020; 3 (1):

Abstract

Nuclear cataract is the most common type of age-related cataract and a leading cause of blindness worldwide. Age-related nuclear cataract is heritable......

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