C9orf72 associates with inactive Rag GTPases and regulates mTORC1-mediated autophagosomal and lysosomal biogenesis

Wang, MM; Wang, HF; Tao, ZT; Xia, Q; Hao, ZB; Prehn, JHM; Zhen, XC; Wang, GH; Ying, Z

Wang, GH; Ying, Z (corresponding author), Soochow Univ, Jiangsu Key Lab Neuropsychiat Dis, Suzhou 215123, Jiangsu, Peoples R China.; Wang, GH; Ying, Z (corresponding author), Soochow Univ, Coll Pharmaceut Sci, Suzhou 215123, Jiangsu, Peoples R China.

AGING CELL, 2020; 19 (4):

Abstract

GGGGCC repeat expansion in C9orf72 is the most common genetic cause in both frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), two......

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