Potent Inhibitors of Plasmodial Serine Hydroxymethyltransferase (SHMT) Featuring a Spirocyclic Scaffold

Schwertz, G; Witschel, MC; Rottmann, M; Leartsakulpanich, U; Chitnumsub, P; Jaruwat, A; Amornwatcharapong, W; Ittarat, W; Schafer, A; Aponte, RA; Trapp, N; Chaiyen, P; Diederich, F

Diederich, F (reprint author), Swiss Fed Inst Technol, Lab Organ Chem, Vladimir Prelog Weg 3, CH-8093 Zurich, Switzerland.

CHEMMEDCHEM, 2018; 13 (9): 931

Abstract

With the discovery that serine hydroxymethyltransferase (SHMT) is a druggable target for antimalarials, the aim of this study was to design novel inhi......

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