Efficacy and Safety of Telaglenastat Plus Cabozantinib vs Placebo Plus Cabozantinib in Patients With Advanced Renal Cell Carcinoma The CANTATA Randomized Clinical Trial

Tannir, NM; Agarwal, N; Porta, C; Lawrence, NJ; Motzer, R; McGregor, B; Lee, RJ; Jain, RK; Davis, N; Appleman, LJ; Goodman, O; Stadler, WM; Gandhi, S; Geynisman, DM; Iacovelli, R; Mellado, B; Sanchez, JMS; Figlin, R; Powles, T; Akella, L; Orford, K; Escudier, B

Tannir, NM (通讯作者)，Univ Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Div Canc Med, 1155 Pressler St, Houston, TX 77030 USA.

JAMA ONCOLOGY, 2022; 8 (10): 1411

Abstract

IMPORTANCE Dysregulated metabolism is a hallmark of renal cell carcinoma (RCC). Glutaminase is a key enzyme that fuels tumor growth by converting glut......

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