Gasdermin D maintains bone mass by rewiring the endo-lysosomal pathway of osteoclastic bone resorption

Li, MB; Yang, DH; Yan, HG; Tang, ZB; Jiang, DL; Chi, ZX; Zhang, J; Nie, WY; Zhen, WX; Yu, WW; Chen, S; Wang, Z; Yu, QZ; Zhang, X; Yang, F; Fan, SW; Lin, XF; Wang, D

Fan, SW; Lin, XF; Wang, D (通讯作者)，Zhejiang Univ, Sir Run Run Shaw Hosp, Inst Immunol, Dept Orthopaed SurgSch Med, Hangzhou 310058, Peoples R China.;Wang, D (通讯作者)，Zhejiang Univ, Liangzhu Lab, Med Ctr, 1369 West Wenyi Rd, Hangzhou, Peoples R China.

DEVELOPMENTAL CELL, 2022; 57 (20): 2365

Abstract

Gasdermin D (GSDMD)-mediated pyroptosis induces immunogenic cell death and promotes inflammation. However, the functions of GSDMD in tissue homeostasi......

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