Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis

Steger, M; Diez, F; Dhekne, HS; Lis, P; Nirujogi, RS; Karayel, O; Tonelli, F; Martinez, TN; Lorentzen, E; Pfeffer, SR; Alessi, DR; Mann, M

Mann, M (reprint author), Max Planck Inst Biochem, Dept Prote & Signal Transduct, Martinsried, Germany.; Alessi, DR (reprint author), Univ Dundee, Sch Life Sci, Med Res Council, Prot Phosphorylat & Ubiquitylat Unit, Dundee, Scotland.

ELIFE, 2017; 6 ( ):

Abstract

We previously reported that Parkinson's disease (PD) kinase LRRK2 phosphorylates a subset of Rab GTPases on a conserved residue in their switch-II dom......

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