IFN-kappa suppresses the replication of influenza A viruses through the IFNAR-MAPK-Fos-CHD6 axis

He, YQ; Fu, WH; Cao, KL; He, Q; Ding, XQ; Chen, J; Zhu, LY; Chen, TY; Ding, LF; Yang, Y; Zhu, CS; Yuan, SH; Li, ZJ; Zhao, C; Zhang, XY; Xu, JQ

Zhao, C; Zhang, XY; Xu, JQ (corresponding author), Fudan Univ, Shanghai Med Coll, Shanghai Publ Hlth Clin Ctr, Shanghai 201508, Peoples R China.; Zhao, C; Zhang, XY; Xu, JQ (corresponding author), Fudan Univ, Shanghai Med Coll, Inst Biomed Sci, Shanghai 201508, Peoples R China.; Zhang, XY; Xu, JQ (corresponding author), China Ctr Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Beijing 102206, Peoples R China.

SCIENCE SIGNALING, 2020; 13 (626):

Abstract

Type I interferons (IFNs) are the first line of defense against viral infection. Using a mouse model of influenza A virus infection, we found that IFN......

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