Dysfunctional endogenous FIX impairs prophylaxis in a mouse hemophilia B model

Cooley, B; Broze, GJ; Mann, DM; Lin, FC; Pedersen, LG; Stafford, DW

Stafford, DW (reprint author), Univ N Carolina, Dept Biol & Pathol, 442 Wilson Hall,South Rd, Chapel Hill, NC 27515 USA.

BLOOD, 2019; 133 (22): 2445

Abstract

Factor IX (FIX) binds to collagen IV (Col4) in the subendothelial basement membrane. In hemophilia B, this FIX-Col4 interaction reduces the plasma rec......

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