Radiotherapy Synergizes with the Hypoxia-Activated Prodrug Evofosfamide: In Vitro and In Vivo Studies

Takakusagi, Y; Kishimoto, S; Naz, S; Matsumoto, S; Saito, K; Hart, CP; Mitchell, JB; Krishna, MC

Krishna, MC (reprint author), NCI, Radiat Biol Branch, Ctr Canc Res, Bldg 10,Room B3-B69, Bethesda, MD 20892 USA.

ANTIOXIDANTS & REDOX SIGNALING, 2018; 28 (2): 131

Abstract

Aims: Evofosfamide (TH-302) is a hypoxia-activated prodrug (HAP) that releases the DNA-damaging bromo-isophosphoramide mustard (Br-IPM) moiety selecti......

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