Pyridoxal-5 '-phosphate-dependent enzyme GenB3 Catalyzes C-3 ',4 '-dideoxygenation in gentamicin biosynthesis

Zhou, ST; Chen, XT; Ni, XP; Liu, Y; Zhang, H; Dong, M; Xia, HZ

Ni, XP; Xia, HZ (corresponding author), Shenyang Pharmaceut Univ, Sch Life Sci & Biopharmaceut, Benxi 117004, Peoples R China.; Dong, M (corresponding author), Tianjin Univ, Frontiers Sci Ctr Synthet Biol, Sch Chem Engn & Technol, Key Lab Syst Bioengn MOE, Tianjin 300072, Peoples R China.

MICROBIAL CELL FACTORIES, 2021; 20 (1):

Abstract

Background: The C-3',4'-dideoxygenation structure in gentamicin can prevent deactivation by aminoglycoside 3'-phosphotransferase (APH(3')) in drug-res......

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