Non-IDH1-R132H IDH1/2 mutations are associated with increased DNA methylation and improved survival in astrocytomas, compared to IDH1-R132H mutations

Tesileanu, CMS; Vallentgoed, WR; Sanson, M; Taal, W; Clement, PM; Wick, W; Brandes, AA; Baurain, JF; Chinot, OL; Wheeler, H; Gill, S; Griffin, M; Rogers, L; Ruda, R; Weller, M; McBain, C; Reijneveld, J; Enting, RH; Caparrotti, F; Lesimple, T; Clenton, S; Gijtenbeek, A; Lim, E; de Vos, F; Mulholland, PJ; Taphoorn, MJB; de Heer, I; Hoogstrate, Y; de Wit, M; Boggiani, L; Venneker, S; Oosting, J; Bovee, JVMG; Erridge, S; Vogelbaum, MA; Nowak, AK; Mason, WP; Kros, JM; Wesseling, P; Aldape, K; Jenkins, RB; Dubbink, HJ; Baumert, B; Golfinopoulos, V; Gorlia, T; van den Bent, M; French, PJ

French, PJ (corresponding author), Erasmus MC Canc Inst Rotterdam, Dept Neurol, Brain Tumor Ctr, POB 2040, NL-3000 CA Rotterdam, Netherlands.

ACTA NEUROPATHOLOGICA, ; ():

Abstract

Somatic mutations in the isocitrate dehydrogenase genes IDH1 and IDH2 occur at high frequency in several tumour types. Even though these mutations are......

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