Design, synthesis, and biological evaluation of 5-aminotetrahydroquinoline-based LSD1 inhibitors acting on Asp375

Yan, JK; Gu, YT; Sun, YX; Zhang, ZH; Zhang, XY; Wang, XR; Wu, TX; Zhao, DM; Cheng, MS

Zhao, DM (corresponding author), Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Peoples R China.

ARCHIV DER PHARMAZIE, 2021; 354 (8):

Abstract

The abnormal expression of lysine-specific histone demethylase 1 (LSD1) is associated with different cancer types, and LSD1 inhibitory activity seems ......

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