ABCB1 limits the cytotoxic activity of TAK-243, an inhibitor of the ubiquitin-activating enzyme UBA1

Wu, ZX; Yang, YQ; Lei, ZN; Narayanan, S; Wang, JQ; Teng, QX; Murakami, M; Ambudkar, SV; Ping, FF; Chen, ZS

Chen, ZS (通讯作者),St Johns Univ, Dept Pharmaceut Sci, Coll Pharm & Hlth Sci, Queens, NY 11439 USA.;Ping, FF (通讯作者),Nanjing Med Univ, Dept Reprod Med, Wuxi Peoples Hosp, Wuxi 214023, Jiangsu, Peoples R China.

FRONTIERS IN BIOSCIENCE-LANDMARK, 2022; 27 (1):

Abstract

Background: One of the major concerns of cancer therapy is the emergence of multidrug resistance (MDR). The MDR-associated ATP-binding cassette sub-fa......

Full Text Link