Overcoming Resistance to DNA-Targeted Agents by Epigenetic Activation of Schlafen 11 (SLFN11) Expression with Class I Histone Deacetylase Inhibitors

Tang, SW; Thomas, A; Murai, J; Trepel, JB; Bates, SE; Rajapakse, VN; Pommier, Y

Pommier, Y (reprint author), NCI, 31 Ctr Dr,Bldg 37,Room 5068, Bethesda, MD 20892 USA.

CLINICAL CANCER RESEARCH, 2018; 24 (8): 1944

Abstract

Purpose: Schlafen 11 (SLFN11), a putative DNA/RNA helicase is a dominant genomic determinant of response to DNA-damaging agents and is frequently not ......

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