Apelin-13 Reverses Bupivacaine-Induced Cardiotoxicity via the Adenosine Monophosphate-Activated Protein Kinase Pathway

Ye, YC; Cai, YY; Xia, EJ; Shi, KJ; Jin, ZS; Chen, HF; Xia, FF; Xia, Y; Papadimos, TJ; Xu, XZ; Liu, L; Wang, QG

Liu, L; Wang, QG (corresponding author), Wenzhou Med Univ, Dept Anesthesiol, Affiliated Hosp 1, Wenzhou, Zhejiang, Peoples R China.

ANESTHESIA AND ANALGESIA, 2021; 133 (4): 1048

Abstract

BACKGROUND: Cardiotoxicity can be induced by the commonly used amide local anesthetic, bupivacaine. Bupivacaine can inhibit protein kinase B (AKT) pho......

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