Loss of heterochromatin and retrotransposon silencing as determinants in oocyte aging

Wasserzug-Pash, P; Rothman, R; Reich, E; Zecharyahu, L; Schonberger, O; Weiss, Y; Srebnik, N; Cohen-Hadad, Y; Weintraub, A; Ben-Ami, I; Holzer, H; Klutstein, M

Klutstein, M (通讯作者),Hebrew Univ Jerusalem, Fac Dent Med, Inst Dent Sci, POB 12272, IL-9112001 Jerusalem, Israel.

AGING CELL, 2022; 21 (3):

Abstract

Mammalian oocyte quality reduces with age. We show that prior to the occurrence of significant aneuploidy (9M in mouse), heterochromatin histone marks......

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