Structure-based discovery of Licoflavone B and Ginkgetin targeting c-Myc G-quadruplex to suppress c-Myc transcription and myeloma growth

Liu, LL; Geng, XJ; Zhang, JY; Li, SH; Gao, J

Gao, J (通讯作者),Xuzhou Med Univ, Jiangsu Key Lab New Drug Res & Clin Pharm, Xuzhou 221004, Jiangsu, Peoples R China.

CHEMICAL BIOLOGY & DRUG DESIGN, 2022; 100 (4): 525

Abstract

G-quadruplex (G4), present in the c-Myc promoter, has emerged as an attractive cancer-specific molecular target for drug development. So, the discover......

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