A modular dCas9-SunTag DNMT3A epigenome editing system overcomes pervasive off-target activity of direct fusion dCas9-DNMT3A constructs

Pflueger, C; Tan, D; Swain, T; Nguyen, T; Pflueger, J; Nefzger, C; Polo, JM; Ford, E; Lister, R

Ford, E; Lister, R (reprint author), Univ Western Australia, Sch Mol Sci, Australian Res Council, Ctr Excellence Plant Energy Biol, Crawley, WA 6009, Australia.; Lister, R (reprint author), Harry Perkins Inst Med Res, Nedlands, WA 6009, Australia.

GENOME RESEARCH, 2018; 28 (8): 1193

Abstract

Detection of DNA methylation in the genome has been possible for decades; however, the ability to deliberately and specifically manipulate local DNA m......

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