Somatic inflammatory gene mutations in human ulcerative colitis epithelium

Nanki, K; Fujii, M; Shimokawa, M; Matano, M; Nishikori, S; Date, S; Takano, A; Toshimitsu, K; Ohta, Y; Takahashi, S; Sugimoto, S; Ishimaru, K; Kawasaki, K; Nagai, Y; Ishii, R; Yoshida, K; Sasaki, N; Hibi, T; Ishihara, S; Kanai, T; Sato, T

Sato, T (corresponding author), Keio Univ, Dept Organoid Med, Sch Med, Tokyo, Japan.; Sato, T (corresponding author), Keio Univ, Dept Gastroenterol, Sch Med, Tokyo, Japan.

NATURE, 2020; 577 (7789): 254

Abstract

With ageing, normal human tissues experience an expansion of somatic clones that carry cancer mutations(1-7). However, whether such clonal expansion e......

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