Bax and Bak knockout apoptosis-resistant Chinese hamster ovary cell lines significantly improve culture viability and titer in intensified fed-batch culture process

Tang, DM; Lam, C; Bauer, N; Auslaender, S; Snedecor, B; Laird, MW; Misaghi, S

Tang, DM; Misaghi, S (通讯作者),Genentech Inc, Dept Cell Culture & Bioproc Operat, 1 DNA Way, San Francisco, CA 94080 USA.

BIOTECHNOLOGY PROGRESS, 2022; 38 (2):

Abstract

In the field of therapeutic protein production, process intensification strategies entailing higher starting cell seeding densities, can potentially i......

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