TIP30 counteracts cardiac hypertrophy and failure by inhibiting translational elongation

Grund, A; Szaroszyk, M; Korf-Klingebiel, M; Mohammadi, MM; Trogisch, FA; Schrameck, U; Gigina, A; Tiedje, C; Gaestel, M; Kraft, T; Hegermann, J; Batkai, S; Thum, T; Perrot, A; dos Remedios, C; Riechert, E; Volkers, M; Doroudgar, S; Jungmann, A; Bauer

Heineke, J (reprint author), Hannover Med Sch, Dept Cardiol & Angiol, Hannover, Germany.; Heineke, J (reprint author), Heidelberg Univ, Med Fac Mannheim, European Ctr Angiosci ECAS, Dept Cardiovasc Res, Mannheim, Germany.; Heineke, J (reprint author), Han

EMBO MOLECULAR MEDICINE, 2019; 11 (10):

Abstract

Pathological cardiac overload induces myocardial protein synthesis and hypertrophy, which predisposes to heart failure. To inhibit hypertrophy therape......

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