Tacrolimus Causes Hypertension by Increasing Vascular Contractility via RhoA (Ras Homolog Family Member A)/ROCK (Rho-Associated Protein Kinase) Pathway in Mice

Wang, XH; Jiang, S; Fei, LY; Dong, F; Xie, LY; Qiu, XY; Lei, Y; Guo, J; Zhong, M; Ren, XQ; Yang, Y; Zhao, L; Zhang, GS; Wang, HH; Tang, C; Yu, LY; Liu, RS; Patzak, A; Persson, PB; Hultstrom, M; Wei, QC; Lai, EY; Zheng, ZH

Lai, EY (通讯作者),Free Univ Berlin, Berlin, Germany.;Lai, EY (通讯作者),Humboldt Univ, Berlin, Germany.;Lai, EY (通讯作者),Berlin Inst Hlth, Inst Translat Physiol, Berlin, Germany.;Wei, QC (通讯作者),Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Radiat Oncol, Hangzhou, Peoples R China.;Zheng, ZH (通讯作者),Sun Yat Sen Univ, Affiliated Hosp 7, Ctr Kidney & Urol, Dept Nephrol, Shenzhen, Peoples R China.

HYPERTENSION, 2022; 79 (10): 2228

Abstract

Background: To provide tacrolimus is first-line treatment after liver and kidney transplantation. However, hypertension and nephrotoxicity are common ......

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