Oral arsenic administration to humanized UDP-glucuronosyltransferase 1 neonatal mice induces UGT1A1 through a dependence on Nrf2 and PXR

Yang, XJ; Weber, AA; Mennillo, E; Paszek, M; Wong, S; Le, SBA; Teo, JYA; Chang, M; Benner, CW; Tukey, RH; Chen, SJ

Chen, SJ (通讯作者),Univ Calif San Diego, Sch Med, Dept Pharmacol, Lab Environm Toxicol, La Jolla, CA 92103 USA.

JOURNAL OF BIOLOGICAL CHEMISTRY, 2023; 299 (3):

Abstract

Inorganic arsenic (iAs) is an environmental toxicant that can lead to severe health consequences, which can be exacerbated if exposure occurs early in......

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