Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity

Nomura, K; Klejnot, M; Kowalczyk, D; Hock, AK; Sibbet, GJ; Vousden, KH; Huang, DT

Vousden, KH; Huang, DT (reprint author), Canc Res UK Beatson Inst, Garscube Estate, Glasgow, Lanark, Scotland.; Vousden, KH (reprint author), Crick Inst, London, England.

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2017; 24 (7): 578

Abstract

MDM2-MDMX complexes bind the p53 tumor-suppressor protein, inhibiting p53's transcriptional activity and targeting p53 for proteasomal degradation. In......

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